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Tirzepatide showed greater average weight loss than semaglutide in SURMOUNT-5; but the headline isn't the whole story. At 72 weeks, adults treated with tirzepatide lost an average of 20.2% of body weight
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Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately 2 times the MRHD based on body surface area comparisons
