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At 12 weeks: Microdose group: mean 3.2% total body weight loss Standard group: mean 5.8% total body weight loss At 24 weeks, after both groups had titrated to similar maintenance doses (7.5 to 10 mg), the gap narrowed: Microdose group: mean 9.1% total body weight loss Standard group: mean 10.4% total body weight loss The microdose group "caught up" but never fully closed the gap, likely because the first 8 weeks at sub-therapeutic doses produced minimal metabolic effect