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GLP-1 regulates glucose homeostasis by inhibiting glucagon, stimulating insulin release, increasing insulin biosynthesis, increasing β cell proliferation, and decreasing β cell apoptosis in rodents (40)
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In those with existing heart diseases, semaglutide reduced the risk of major cardiovascular events (heart attack, stroke or cardiovascular death) by about 20% over roughly three years, suggesting these metabolic changes translate into real heart protection
