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Tirzepatide (Zepbound): Showed up to 20.9% average weight reduction at the highest dose in the SURMOUNT-1 trial

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113 It was then fused to the constant region (Fc) of modified human immunoglobulin G4 (IgG4) via a “-(Gly-Gly-Gly-Gly-Ser) 3-Ala-“ bridge and exhibits an average biological half-life of 90 h