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Seek medical advice if you experience: Severe or persistent abdominal pain , particularly if accompanied by vomiting, fever, or inability to pass wind—these may indicate bowel obstruction or other serious conditions No bowel movement for more than seven days despite laxative use , as prolonged constipation can lead to faecal impaction Blood in your stools or rectal bleeding , which requires investigation to exclude other causes Unexplained weight loss or persistent vomiting that may indicate complications or alternative diagnoses Severe right-sided upper abdominal pain, fever, or yellowing of the skin or eyes , which could indicate gallbladder problems—GLP-1 receptor agonists like Wegovy are associated with an increased risk of gallstones [18] [8] Severe nausea or vomiting that prevents you from taking fluids or medications , which may lead to dehydration and require medical intervention If you develop symptoms suggestive of pancreatitis—severe, persistent abdominal pain radiating to the back, often with nausea and vomiting—stop taking Wegovy and seek immediate medical attention