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74,83 Nevertheless, although blockade of intra cerebroventricular leptin action with intra cerebroventricular exendin 9 has been replicated in rats, 84 GLP1R −/− mice were found to have a normal anorectic response to exogenous leptin, 85 which either argues against a critical role for central GLP-1 as a downstream mediator of leptin action or suggests developmental compensation
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