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injections of 100 nmol kg −1 MK-801 ( n = 8 rats), 100 nmol kg −1 GLP-1 ( n = 8 rats), 100 nmol kg −1 GLP-1–MK-801 ( n = 8 rats) or vehicle (isotonic saline, n = 8 rats) for three consecutive days while being offered the choice between chow and kaolin

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Importantly, preclinical studies have demonstrated that co-administration of GIP and GLP-1 intracerebroventricularly results in an additive enhancement in weight-lowering efficacy (138)