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7 Still, Le, who is also a general surgery registrar at Royal Melbourne Hospital, says, “I think it is too early to say this is a robust, durable, and generalizable effect given the high heterogeneity of underlying studies.” He notes a need for more rigorous randomized controlled trials with longer follow-up times to better characterize the impact of these medications on weight and OSA together, as well as gain a better understanding of effect size, optimal doses, side effects, interactions with other medications, and impacts on other comorbidities

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A Weibull 3-parameter analysis was employed to examine reports of severe outcomes associated with dehydration to identify temporal patterns of time to onset