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A landmark study in PNAS showed that Akkermansia interacts directly with the intestinal epithelium and that, in mice, administering it reversed key features of diet-induced obesity, including fat mass gain, metabolic inflammation, and gut barrier disruption (Everard et al., 2013)

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Dual GIP and GLP-1 Receptor Agonist Tirzepatide Alleviates Hepatic Steatosis and Modulates Gut Microbiota and Bile Acid Metabolism in Diabetic Mice