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🧪 Drug Class: • GLP-1 Receptor Agonist • Incretin mimetic antidiabetic agent 🎯 Uses / Indications: ✅ Type 2 Diabetes Mellitus ✅ Chronic Weight Management (Obesity) ✅ Cardiovascular risk reduction in patients with T2DM ✅ Glycemic control with lifestyle modification ⚙️ Mechanism of Action: • Activates GLP-1 receptors • Increases glucose-dependent insulin secretion • Suppresses glucagon release • Delays gastric emptying • Promotes satiety and weight loss 💊 Dose: • Subcutaneous: • Start 0.25 mg once weekly for 4 weeks • Increase to 0.5 mg once weekly • May increase gradually up to 2.4 mg weekly depending on indication • Oral: • 3 mg once daily initially • Take on an empty stomach with a small amount of water ⚠️ Adverse Effects: • Nausea • Vomiting • Diarrhea • Decreased appetite • Pancreatitis (rare) • Gallbladder disease 🚫 Contraindications: • Personal or family history of Medullary Thyroid Carcinoma (MTC) • Multiple Endocrine Neoplasia syndrome type 2 (MEN2) • Hypersensitivity to semaglutide • Severe gastrointestinal disease (use with caution) 🔄 Drug Interactions: • Insulin / Sulfonylureas → ↑ risk of hypoglycemia • Delayed gastric emptying → altered absorption of oral drugs • Warfarin → monitor INR carefully • Alcohol → ↑ GI adverse effects ⭐ Brand Names: • Ozempic • Wegovy • Rybelsus 💡 Clinical Pearl: Semaglutide significantly improves HbA1c levels, promotes substantial weight loss, and reduces cardiovascular risk, making it a powerful therapy in modern Type 2 Diabetes and obesity management