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Importantly, GLP-1 injection into the ARC was shown to decrease the activity of agouti-related peptide (AgRP) neurons and their strong orexigenic effect and to activate the pro-opiomelanincortin (POMC) neurons, which are prominent in satiety via melanocortin pathways [50,55,56]

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Weekly doses may be fractionated into twice-weekly administrations (e.g., 0.5 mg biweekly) to support tolerability or administration preferences