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GLP-1 injections are not your only option when considering medical weight loss. Weekly injections dominate the headlines, but daily oral alternatives like Qsymia and Contrave are highly effective and completely needle-free tools.

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For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]