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GLP-1 receptor agonists as promising anti-inflammatory agents in heart failure with preserved ejection fraction - PMC
Historically, pharmacology has targeted these receptors in isolation: - Liraglutide / semaglutide — selective GLP-1 agonists - Tirzepatide — dual GIP/GLP-1 agonist - Retatrutide — triple GIP/GLP-1/glucagon agonist The rationale for glucagon co-agonism is that glucagon receptor activation increases energy expenditure and lipolysis — complementing the appetite and insulin effects of GLP-1/GIP
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