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4 Impact of Spatial Segregation in the Gut on Obesity and T2D The intestinal barrier (compare insert in Figure 1 ) is a complex system comprising (i) an immunological barrier, which consists of immune cells, cytokines and IgA as discussed in the previous section, (ii) a chemical barrier, which is characterized by antimicrobial secretions and (iii) a physical barrier, which involves spatial segregation through mucus and epithelial cells that provide a barrier through intercellular tight junctions
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