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When investigators applied the treatment policy estimand, individuals administered semaglutide achieved superior weight loss of 15.1% compared to a reduction of 2.4% with the placebo and 84.9% achieved a weight loss of 5% or more compared to the placebo at 25.8%
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GLP-1RAs have been proven to reduce the risk of major adverse cardiovascular events (MACE) occurrence, including death from cardiovascular causes, non-fatal myocardial infarction and non-fatal stroke, as well as all-cause mortality in T2DM and patients with obesity (26–28)
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