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Distribution and Regulation of GLP-1 System Although a deficiency in GLP-1 is unlikely to directly impair the pathophysiology of T2DM,20 reduced GLP-1 levels may contribute to the development of T2DM.21 Additionally, weight gain may reflect dysregulation of the GLP-1 system, thereby perpetuating metabolic dysfunction.22 GLP-1 secretion plays a critical role in regulating various homeostatic mechanisms,3,20 some of which overlap between peripheral and central GLP-1 systems
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