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Weight loss alone can reduce apnea — hypopnea events and nighttime oxygen drops. Tirzepatide (Zepbound) is now FDA‑approved specifically to treat OSA in adults with obesity, backed by SURMOUNT‑OSA trials showing large drops in apnea–hypopnea index, hypoxic burden, and body weight versus placebo. Semaglutide is not OSA‑approved but still improves apnea severity in some patients as weight and visceral fat come down, with emerging data suggesting symptom relief and better functional scores. For sleep apnea driven by obesity, both agents can help, but tirzepatide is the one positioned as a direct OSA drug today
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