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Semaglutide Side Effects Week by Week Week 1 — The First Injection Dose: 0.25 mg (sub-therapeutic — adaptation only) What to expect: Mild nausea within 24–72 hours after injection, especially in the evening Reduced appetite — meals feel “less interesting” Possible mild fatigue or headache Slight constipation or, in some patients, loose stools Injection site mildly tender or red (usually resolves within 24 hours) What this week is NOT: It is not the weight loss week
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