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The hormonal biology of menopause is increasingly understood as a contributing factor to that disparity, and the convergence of estrogen and GLP-1 signaling in the brain offers a mechanistic framework for understanding why, and potentially what to do about it

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What Your Doctor Should Know Before Prescribing Either Drug Any prescriber considering phentermine or tirzepatide should obtain a detailed cardiovascular history, recent blood pressure readings, and an EKG if the patient has hypertension, prior arrhythmia, or family history of sudden cardiac death