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Yet by 2000, a strategy had emerged to prolong the effect of GLP-1 signaling: generate DPP-4 resistant peptides that bind and activate (i.e., agonize) GLP-1R
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A phase 2 clinical trial published in The New England Journal of Medicine enrolled 338 patients with a body-mass index of 30 or higher or those with a BMI of 27 to less than 30 with at least one weight-related condition
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