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Even if they know of the risks, patients may underestimate how painful the GI symptoms can be: “They may seem manageable, but there are some extreme cases,” Anand said
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Then in May 2025, the first direct head-to-head trial — SURMOUNT-5 — was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions
