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The pathological mechanism seems to be based on acute tubular necrosis due to dehydration and volume contraction resulting from severe and progressively worsening gastrointestinal symptoms [155]
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In addition to the interplay with GLP-1 activity, these bitter and aromatic herbs can help to mitigate many of the undesirable side effects experienced by many patients using GLP-1 therapies, including constipation and nausea
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