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This may be related to gender-related pharmacokinetic differences (lower clearance of GLP-1RA in females) 41 and postmenopausal changes in gastrointestinal motility 42

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News-Medical+3EurekAlert!+3ASMBS+3 To put numbers on it: Surgical patients lost ~58 lbs in two years (≈ 24% of total body weight, or TBW) GLP-1 patients lost only ~12 lbs (≈ 4.7% TBW) over the same period EurekAlert!+2News-Medical+2 Even among GLP-1 users who continued therapy for a full year, weight loss averaged only ~7% TBW—still far less than surgical outcomes EurekAlert!+2ASMBS+2 Another rigorous analysis published in JAMA Surgery compared weight loss surgery and GLP-1 receptor agonists over two years