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16(5): 555949.DOI: 10.19080/CRDOJ.2023.16.555949 Review Article Abstract Introduction Retatrutide for Treatment of Obesity Retatrutide for Treatment of Type 2 Diabetes Effects of Retatrutide on Cardiovascular Risk Factors Safety of Retatrutide Effect of Retatrutide on Heart Rate Advantages of Retatrutide Limitations of Retatrutide Conclusions and Current Needs References Abstract Retatrutide is a triple hormone agonist of the receptors of glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide (GIP) and glucagon that can be administered subcutaneously once a week

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GLP-1RAs Versus DPP-4is The aggregate crude incidence of thyroid tumors ranged from 0.96 (95% CI 0.90–1.03) to 1.03 (0.91–1.15) per 1,000 person-years in patients initiating GLP-1RAs and 0.94 (0.91–0.97) to 1.13 (1.06–1.20) per 1,000 person-years in patients initiating DPP-4is (Table 2)