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However, these studies did not specifically include patients with kidney disease, and the numbers of hard kidney outcomes reached (i.e., kidney transplantation, initiation of maintenance dialysis, death from kidney failure, or a sustained low GFR) were too low to make definitive conclusions on the renoprotective effects of GLP-1 receptor agonists
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In a Lilly-funded trial comparing Foundayo to Rybelsus, patients with type 2 diabetes on 12 to 36 milligrams of orforglipron lost 15 to 20 pounds on average, while those on 7 to 14 milligrams of Rybelsus lost 8 to 11 pounds
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