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At the bottom of the orthosteric pocket, the side chain of R310 6.40b pointed to the TMD core and formed a cation-pi stacking with Y241 3.44b , where it pointed to ECL3 and made no contact with the TMD core in the GLP-1 bound structure
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[DOI] [PubMed] [Google Scholar] 31.Sanyal A., Charles E.D., Neuschwander-Tetri B.A., Loomba R., A Harrison S., Abdelmalek M.F., Lawitz E.J., Halegoua-DeMarzio D., Kundu S., Noviello S., et al
1 receptor agonists are known to suppress appetite
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