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Professor Adam Balen from the Royal College of Obstetricians and Gynaecologists emphasizes: "A clinician may consider prescribing this medicine 'off-label' if they think it would benefit a patient with PCOS, but this would need a careful discussion with them about the benefits and potential risks." Beyond the physical benefits, these treatments are reshaping how patients view their condition
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SGLT2-i induced natriuresis and glomerular hemodynamics changes resemble, even partially, those observed with sacubitril/valsartan, a first in-class angiotensin receptor neprilysin inhibitor (ARNi)
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