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Exendin-4 became the chemical scaffold for exenatide, and on April 28, 2005, the FDA approved exenatide (Byetta) for type 2 diabetes — the first GLP-1 receptor agonist ever marketed
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Omarigliptin is a long-acting DPP-4 inhibitor for once weekly dosing that is presently approved in Japan, but not in Europe or American countries (20)
