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56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity
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Most likely, the natriuretic effect of GLP-1 in humans is mediated by a tubular mechanism secondary to selective suppression of angiotensin II 28,37
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