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For this population-based study, researchers used medical records from about 45 million people in the United States listed in the TriNetX real-time federated health research network who all had at least one outpatient or inpatient doctor visit between 2011 and 2023
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27,28 However, many trials excluded those at highest risk of suicidality through exclusion criteria or based on investigators’ judgment such that uncertainty remained regarding the generalizability of the findings to broader patient groups, and the statistical power was low due to few events
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