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“Orforglipron and retatrutide from Eli Lilly exemplify the next generation of metabolic therapies: oral formulations that promise improved adherence, triple-hormone mechanisms that deliver superior weight loss and expanded therapeutic applications spanning from brain health to renal disease".” Lilly’s Orforglipron, Retatrutide Named as Defining GLP-1 Drugs of the Next Decade Davy James Key Takeaways Eli Lilly's orforglipron and retatrutide are pivotal in the cardiometabolic market, with significant sales projections by 2031

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Nausea is the most common side effect of semaglutide drugs like Ozempic® and Wegovy®