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Longer-term safety questions — including effects on the pancreas, thyroid, gallbladder, and cardiovascular system — remain under investigation in ongoing Phase 3 trials
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Pioneer 3: This trial examined the safety, efficacy of semaglutide and sitagliptin by selecting 1864 subjects who received once-daily oral 3.0 mg semaglutide (466), or 7.0 mg semaglutide (466), or 14.0 mg semaglutide (465), or 100 mg sitagliptin (467) with dose escalation
