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Gene expression [edit source] The proglucagon gene is expressed in several organs, including the pancreas (α-cells of the islets of Langerhans), gut (intestinal enteroendocrine L-cells) and brain (caudal brainstem and hypothalamus)
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In the fasted state, when glucose levels drop, glucagon is secreted by pancreatic ɑ-cells to trigger the release of stored glucose from the liver to maintain normal blood glucose levels
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