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For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE – heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80
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The team found a way to direct GLP-1 to the area involved in feeling full, while keeping the drug out of the vomit center
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