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Because the cardiovascular benefit of empagliflozin most likely is related to the drug’s hemodynamic benefit, while those of the GLP-1 RAs are related to their anti-atherogenic/anti-inflammatory actions, the two classes of antidiabetic medications may produce an additive cardiovascular benefit (Figure 4)
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It has been hypothesized and tested if an atrial shunt could provide a benefit by reducing left atrial pressures and symptoms
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