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The researchers, led by Ravi Retnakaran, from Mount Sinai Hospital, Toronto, Canada, noted that the high cost of both GLP-1 agonists and insulin analogues is likely to be the major barrier to widespread adoption of the treatment
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One depends on the GLP-1 receptor mediated action with inotropic, glucose uptake stimulating, and ischemic preconditioning effects, and secondly that the GLP-1 receptor independent pathway causes vasodilatation that is mediated by nitric oxide 5
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