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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has well-established weight-loss benefits. Cagrilintide, a long-acting analogue of the satiety hormone amylin, has shown promise for weight loss in early trials. The potential benefit
The next sections discuss what these trials reveal about mechanism: the time course of benefit, the imaging signature of plaque stabilization, and the limits of inference from each trial design
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