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New GLP-1 weight-loss drugs are coming—and they're stronger than Wegovy and Zepbound | Scientific American

doi: 10.1038/s41593-022-01095-5 75 RavizzaTScheperMDi SapiaRGorterJAronicaEVezzaniA

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GLP-1 is released from intestinal L-cells in a biphasic pattern following meal ingestion: an initial early peak within 10–15 minutes, driven primarily by neural and endocrine signals from the upper gastrointestinal tract, is followed by a sustained second peak at 30–60 minutes driven by direct nutrient contact with L-cells in the distal ileum and colon