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High MBGS also overlapped with Hoshida S3, Boyault G5/G6, and Chiang CTNNB1 subclass tumors in TCGA and in HCC spatial transcriptomic datasets visually depicting these tumors to be situated in an immunologically cold tumor microenvironment

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(2023, New England Journal of Medicine) found participants lost up to 17.5% of body weight over 24 weeks, with effects attributed to appetite suppression, improved insulin sensitivity, and increased energy expenditure via glucagon receptor activation