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3 These agents have also been shown to lower levels of circulating proinflammatory cytokines such as TNF-α and IL-6, both implicated in HS pathogenesis, as well as C-reactive protein (CRP), a marker of systemic inflammation that correlates with disease severity
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The SURMOUNT trials demonstrated meaningful weight loss at doses ranging from 5 mg to 15 mg weekly, with greater reductions observed at higher maintenance doses