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The PIONEER program compared oral semaglutide with placebo and active comparators in patients from across the full treatment continuum of type 2 diabetes, recruiting people with newly diagnosed type 2 diabetes and long-term disease, drug-naive patients, and those receiving multiple drug therapies, including insulin (53–62)

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The 2021 Smits semaglutide safety review compiled the GLP-1 component data (PMID 34305810)