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After a meal, intestinal GLP-1 release triggers insulin secretion, slows gastric emptying, and signals satiety to the brain

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“Reports have shown a lower incidence of anxiety and depression in GLP-1 analog users [like semaglutide] compared with nonusers, possibly due to anti-inflammatory effects on neuroinflammation and reduced concern about weight gain,” says Roshani Sanghani, MD, an endocrinologist in private practice who sees patients via telemedicine