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For the assessment of the changes from baseline following GLP-1-based therapies in % FMD and IMT, mean differences with 95% confidence intervals (CI) were calculated between baseline samples and end-of-treatment samples for each study and then an overall effect size was generated
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95% confidence interval, 0.07 to 0.23) and the SCALE IBT trial showed a significant difference in weight loss when liraglutide 3.0 mg was used with IBT (7.5% mean body weight loss), compared to placebo combined with IBT (4.0% mean body weight loss) in individuals with and without diabetes [24]
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