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Over half-a-million individuals who were prescribed one of the GLP-1 RA medications were then categorized into four groups based on diagnoses of diabetes and obesity/overweight identified in claims data: Diabetes and no obesity/overweight Diabetes and obesity/overweight No diagnosis of diabetes nor obesity/overweight No diagnosis of diabetes with an obesity/overweight diagnosis The authors found that GLP-1 RA prescribing patterns varied significantly across diabetics and nondiabetics
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Clinical trials show most weight regain happens within 12 months after stopping GLP-1 therapy, with patients returning to 50–70% of lost weight
