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Furthermore, nausea is among the most common side effects associated with GLP-1 receptor agonists in humans ( A limitation of the present study is the use of male rats, as sex-dependent differences have been reported across different stages of METH addiction in both humans and rodents (Yang et al., 2025), whereas preclinical studies have shown stronger suppression of alcohol self-administration and reinstatement in males, with females exhibiting less pronounced behavioral effects (Vallöf et al., 2020)
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