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Statistical Analysis To address potential confounding, cohorts were balanced using 1:1 greedy nearest-neighbor propensity score matching based on age at index, sex, race, ethnicity, BMI ≥ 30, HbA1c ≥ 8, and comorbidities including tobacco use, alcohol use, hypertension, diabetes mellitus, hyperlipidemia, obesity, presence of pancreatic cysts, and use of anti-diabetic medications (insulin, metformin, and SGLT-2 inhibitors)
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FIGURE 4 Berberine activated GLP-1/GLP-1R/PKA signaling pathway in Min6 cell Min6 cell is a cell line established in insulinoma obtained by targeted expression in transgenic mice, and retains the physiological characteristics of normal β cell
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