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Similarly, distal delivery of the best known aminoacidic GLP-1-secretagogue, glutamine, has proven ineffective at ameliorating glucose tolerance in both healthy and diabetic subjects (407–409)
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Class B GPCR Architecture and the Peptide Paradigm Understanding why orforglipron's mechanism is significant requires an appreciation of the GLP-1 receptor's molecular architecture and the historical challenges of targeting class B GPCRs with small molecules
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