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In fact, one could predict that increased direct nutrient stimulation of intestinal GLP-1-producing neurons in patients with Roux-en-Y gastric bypass leads to increased GLP-1 secretion
Follistatin 344
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This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover
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