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Acknowledgements This study is funded by grants from the MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, an FP7-HEALTH-2009-241592 EuroCHIP grant and is supported by the NIHR Imperial Biomedical Research Centre Funding Scheme

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Studies have shown that in ob/ob mouse hepatocytes and liver tissues, berberine facilitates cAMP degradation, thereby inhibiting CREB phosphorylation and subsequently reducing Pepck and G6pase mRNA levels [44]