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Keywords: drug-induced colitis, gastrointestinal bleeding, ischemic colitis, tirzepatide, weight loss and obesity Introduction Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that enhances glucose-dependent insulin secretion, delays gastric emptying, and promotes satiety, leading to clinically meaningful weight reduction

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By constructing dynamic network topologies of the gut-adipose-ovary axis, researchers can isolate critical mechanistic nodes, such as rate-limiting metabolic enzymes or specific signaling receptors, that drive pathological progression